I think as much as I hate yet another fraction-decreasing study, the ideas behind this HYPNO study were pretty cool.
The trial was ran in this part of the world... maybe 66/33 is used a lot there, IDK. But it has a time-adjusted EQD2 of about 70/35, so it should be fine to consider it as essentially equivalent to 70/35 imho.
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As far as the rationale for the study, here it is. It's all based on LQ. I think we see yet another GIANT win for the LQ model in this study in that LQ has yet to be invalidated. Be careful about thinking LQ doesn't work. It's the basis for decreasing prostate fractions, why 5 fraction breast works, etc. We have a model that predicted gravitational waves (I'm speaking metaphorically obv).
The waves were found. The waves are now admittedly rocking everyone's reimbursement boat!
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